Case Commentary: Delayed Cerebral Vasculitis Associated with the Development of Ceftriaxone-Resistant Pneumococcal Meningitis

Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02251-19. doi: 10.1128/AAC.02251-19. Print 2020 Feb 21.

Abstract

Mizrahi and colleagues present a well-described case of the emergence of drug resistance in Streptococcus pneumoniae meningitis during therapy with ceftriaxone monotherapy with a low bactericidal concentration in the cerebrospinal fluid. Adherence to international guidelines could possibly have prevented the emergence of this resistant isolate and the adverse outcome.

Keywords: meningitis.

Publication types

  • Case Reports

MeSH terms

  • Ceftriaxone / pharmacology*
  • Humans
  • Meningitis, Pneumococcal / microbiology*
  • Microbial Sensitivity Tests
  • Mutation
  • Vasculitis, Central Nervous System / microbiology*

Substances

  • Ceftriaxone