Unwinding 20 Years of the Archaeal Minichromosome Maintenance Helicase

J Bacteriol. 2020 Feb 25;202(6):e00729-19. doi: 10.1128/JB.00729-19. Print 2020 Feb 25.

Abstract

Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and eukarya, and, in the mid-1990s, in archaea. This year marks the 20th anniversary of the first report on the archaeal replicative helicase, the minichromosome maintenance (MCM) protein. This minireview summarizes 2 decades of work on the archaeal MCM.

Keywords: DNA replication; MCM; archaea; helicase; minichromosome maintenance; three-dimensional structure.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Archaea / enzymology*
  • Archaea / genetics*
  • Archaeal Proteins / genetics
  • Archaeal Proteins / metabolism
  • Bacteria / genetics
  • Bacteria / metabolism
  • DNA Replication
  • DNA, Archaeal
  • Eukaryota / genetics
  • Eukaryota / metabolism
  • History, 20th Century
  • History, 21st Century
  • Minichromosome Maintenance Proteins / chemistry
  • Minichromosome Maintenance Proteins / genetics*
  • Minichromosome Maintenance Proteins / metabolism*
  • Protein Domains
  • Research* / history
  • Structure-Activity Relationship

Substances

  • Archaeal Proteins
  • DNA, Archaeal
  • Minichromosome Maintenance Proteins