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Review
. 2020 Feb;27(2):405-419.
doi: 10.1038/s41418-019-0486-3. Epub 2020 Jan 6.

Saga of Mcl-1: Regulation From Transcription to Degradation

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Free PMC article
Review

Saga of Mcl-1: Regulation From Transcription to Degradation

Viacheslav V Senichkin et al. Cell Death Differ. .
Free PMC article

Abstract

The members of the Bcl-2 family are the central regulators of various cell death modalities. Some of these proteins contribute to apoptosis, while others counteract this type of programmed cell death, thus balancing cell demise and survival. A disruption of this balance leads to the development of various diseases, including cancer. Therefore, understanding the mechanisms that underlie the regulation of proteins of the Bcl-2 family is of great importance for biomedical research. Among the members of the Bcl-2 family, antiapoptotic protein Mcl-1 is characterized by a short half-life, which renders this protein highly sensitive to changes in its synthesis or degradation. Hence, the regulation of Mcl-1 is of particular scientific interest, and the study of Mcl-1 modulators could aid in the understanding of the mechanisms of disease development and the ways of their treatment. Here, we summarize the present knowledge regarding the regulation of Mcl-1, from transcription to degradation, focusing on aspects that have not yet been described in detail.

Conflict of interest statement

The authors declare that they have no conflict of interest.

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