Progressive ankylosis in mice. An animal model of spondylarthropathy. I. Clinical and radiographic findings

Arthritis Rheum. 1988 Nov;31(11):1390-9. doi: 10.1002/art.1780311108.


To determine its similarity to human spondylarthropathies, we studied murine progressive ankylosis, a spontaneously occurring disorder of joints in mice. Clinically, peripheral joints were inflamed initially, then became ankylosed in a predictable sequence from distal to proximal. Forefeet were involved before hindfeet. Axial joint involvement produced severe spinal ankylosis. Extraarticular manifestations included balanitis and crusting skin lesions. Radiographically, bony erosions and calcification of articular and periarticular tissues were extensive, and vertebral syndesmophytes produced a "bamboo" spine. We conclude that progressive ankylosis is a systemic disease with many clinical and radiographic similarities to human spondylarthropathies, and it may represent a useful animal model for the study of the human diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Ankylosis / diagnostic imaging
  • Ankylosis / physiopathology
  • Ankylosis / veterinary*
  • Arthrography
  • Blood Chemical Analysis
  • Disease Models, Animal*
  • Female
  • Foot / diagnostic imaging
  • Foot / pathology
  • Male
  • Mice
  • Mice, Inbred Strains
  • Rheumatoid Factor / analysis
  • Rodent Diseases / diagnostic imaging*
  • Rodent Diseases / pathology
  • Rodent Diseases / physiopathology
  • Spinal Diseases / diagnostic imaging
  • Spinal Diseases / physiopathology
  • Spinal Diseases / veterinary*


  • Rheumatoid Factor