Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy

Onco Targets Ther. 2019 Dec 19;12:11291-11304. doi: 10.2147/OTT.S232852. eCollection 2019.

Abstract

Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activities. In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data.

Keywords: autophagy; cancer; ferroptosis; iron; p53.

Publication types

  • Review

Grant support

This study was funded by the National Natural Science Foundation of China (No. 81760526 and No. 81802794) and Yunnan Provincial Research Foundation for Basic Research, China (No. 2018FB135).