Radiotherapy in the management of vaginal intraepithelial neoplasia after hysterectomy

Br J Obstet Gynaecol. 1988 Oct;95(10):976-9. doi: 10.1111/j.1471-0528.1988.tb06500.x.


Intravaginal radium was used to treat 11 patients who were found to have vaginal intraepithelial neoplasia (VAIN) following hysterectomy for cervical intraepithelial neoplasia. All were discovered by cytological follow-up, were colposcopically assessed and diagnosis was confirmed by histological examination before treatment. Nine of 10 patients questioned continue to enjoy satisfactory sexual intercourse after treatment but 6 of 8 premenopausal patients subsequently became oestrogen deficient and required hormone replacement therapy. No other significant morbidity has been observed. All remain cytologically and colposcopically free of disease after a median follow-up of 26 months. We conclude that radiotherapy is an effective treatment of VAIN following hysterectomy.

MeSH terms

  • Adult
  • Aged
  • Carcinoma in Situ / radiotherapy*
  • Female
  • Humans
  • Hysterectomy*
  • Middle Aged
  • Postoperative Complications / radiotherapy*
  • Prospective Studies
  • Vaginal Neoplasms / radiotherapy*