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. 2020 Feb;43(2):77-79.
doi: 10.1016/j.tins.2019.12.001. Epub 2020 Jan 3.

Is Ca2+ Essential for Synaptic Vesicle Endocytosis?

Natali L Chanaday  1 , Ege T Kavalali  2
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Is Ca2+ Essential for Synaptic Vesicle Endocytosis?

Natali L Chanaday et al. Trends Neurosci. 2020 Feb.

Abstract

Synaptic vesicle fusion is coupled to swift retrieval of vesicle components from the synaptic plasma membrane. Ca2+ has been assumed to be a key mediator of this coupling. In a recent study, Orlando et al. unequivocally demonstrate that Ca2+ is not essential for synaptic vesicle retrieval.

Keywords: hypertonic stimulation; synaptic vesicle; synaptic vesicle endocytosis.

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