HHV-8-negative multicentric Castleman disease presenting as a crescentic immune complexes membranoproliferative glomerulonephritis

BMJ Case Rep. 2020 Jan 6;13(1):e231844. doi: 10.1136/bcr-2019-231844.

Abstract

Multicentric Castleman disease is a rare polyclonal lymphoproliferative disorder mainly associated with two renal manifestations: thrombotic microangiopathy and amyloidosis. Nevertheless, we report here a case of human herpes virus-8 negative multicentric Castleman disease with membranous proliferative glomerulonephritis and extracapillary proliferation. A patient was successfully treated with corticosteroids, anti-CD20 and cyclophosphamide therapy.

Keywords: acute renal failure; proteinurea.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Antigen-Antibody Complex
  • Castleman Disease / complications*
  • Castleman Disease / drug therapy
  • Cyclophosphamide / therapeutic use
  • Diagnosis, Differential
  • Drug Therapy, Combination
  • Glomerulonephritis, Membranoproliferative / drug therapy
  • Glomerulonephritis, Membranoproliferative / etiology*
  • Herpesvirus 8, Human
  • Humans
  • Immunologic Factors / therapeutic use
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Middle Aged
  • Rituximab / therapeutic use

Substances

  • Adrenal Cortex Hormones
  • Antigen-Antibody Complex
  • Immunologic Factors
  • Immunosuppressive Agents
  • Rituximab
  • Cyclophosphamide

Supplementary concepts

  • Multi-centric Castleman's Disease