Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder

Cell Mol Neurobiol. 2020 Aug;40(6):1049-1056. doi: 10.1007/s10571-019-00782-5. Epub 2020 Jan 7.

Abstract

The purpose of the preliminary study was to determine whether the occurrence of certain SNPs of genes encoding IL-1α, IL-1β, and TNF-α is associated with the development of depression. Five polymorphisms were selected: i.e. c.-1560G > C-IL-1β (rs1143623), c. -118 C > T-IL-1β (rs1143627), c.340G > T-IL-1α (rs17561), c.-1211T > C-TNF-α (rs1799964) and c.-488G > A-TNF-α (rs1800629). These were analyzed using TaqMan probes. The genotypes of the analyzed polymorphisms were found to be associated with disease severity and may affect the effectiveness of antidepressant therapy. In addition, the gene-gene analysis confirmed that combined genotypes of investigated SNPs may modulate the risk of depression.

Keywords: Cytokine; Inflammation; Major depressive disorder; Single nucleotide polymorphism.

MeSH terms

  • Depressive Disorder, Major / epidemiology*
  • Depressive Disorder, Major / genetics*
  • Epigenesis, Genetic
  • Genetic Predisposition to Disease*
  • Humans
  • Interleukin-1alpha / genetics*
  • Interleukin-1beta / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Severity of Illness Index*
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • IL1A protein, human
  • IL1B protein, human
  • Interleukin-1alpha
  • Interleukin-1beta
  • Tumor Necrosis Factor-alpha