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. 2019 Dec 12;2019:6708474.
doi: 10.1155/2019/6708474. eCollection 2019.

Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma

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Free PMC article

Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma

Makoto Emori et al. Int J Surg Oncol. .
Free PMC article

Abstract

Background: Lymph node metastasis (LNM) is a relatively rare event in soft tissue sarcoma. An association between the timing of LNM detection and patient prognosis is presently unknown.

Patients and methods: We retrospectively analyzed the clinicopathological features of 33 patients with LNM between 2001 and 2015. Analysis of the timing of LNM diagnosis was grouped according to patients presenting LNM in either <8 months (the median time from primary tumor diagnosis to LNM) or ≥8 months after primary tumor diagnosis.

Results: A relationship between the primary tumor size and the timing of the LNM was not significantly found (Rs = 0.0088, p=0.96). Sixteen patients had an LNM detection duration of <8 months, and 17 patients had a duration of ≥8 months. The 5-year survival for patients with an LNM detection duration of <8 months and ≥8 months was 19% and 71%, respectively (p=0.0016). There were 19 patients with pulmonary metastases. Among them, there were 13 patients with a duration of primary tumor diagnosis to LNM of <8 months and 6 with a duration of ≥8 months (p=0.01).

Conclusion: Early LNM (<8 months) may predict poor prognosis in soft tissue sarcoma.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
5-year OS rate of patients with lymph node metastases.
Figure 2
Figure 2
5-year OS rate of patients with time of diagnosis for lymph node metastases of <8 months and ≥8 months.
Figure 3
Figure 3
5-year OS rate of patients receiving any treatment and those receiving no treatment for lymph node metastasis.

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