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. 2019 Dec 12;2019:6708474.
doi: 10.1155/2019/6708474. eCollection 2019.

Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma

Free PMC article

Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma

Makoto Emori et al. Int J Surg Oncol. .
Free PMC article


Background: Lymph node metastasis (LNM) is a relatively rare event in soft tissue sarcoma. An association between the timing of LNM detection and patient prognosis is presently unknown.

Patients and methods: We retrospectively analyzed the clinicopathological features of 33 patients with LNM between 2001 and 2015. Analysis of the timing of LNM diagnosis was grouped according to patients presenting LNM in either <8 months (the median time from primary tumor diagnosis to LNM) or ≥8 months after primary tumor diagnosis.

Results: A relationship between the primary tumor size and the timing of the LNM was not significantly found (Rs = 0.0088, p=0.96). Sixteen patients had an LNM detection duration of <8 months, and 17 patients had a duration of ≥8 months. The 5-year survival for patients with an LNM detection duration of <8 months and ≥8 months was 19% and 71%, respectively (p=0.0016). There were 19 patients with pulmonary metastases. Among them, there were 13 patients with a duration of primary tumor diagnosis to LNM of <8 months and 6 with a duration of ≥8 months (p=0.01).

Conclusion: Early LNM (<8 months) may predict poor prognosis in soft tissue sarcoma.

Conflict of interest statement

The authors declare that they have no conflicts of interest.


Figure 1
Figure 1
5-year OS rate of patients with lymph node metastases.
Figure 2
Figure 2
5-year OS rate of patients with time of diagnosis for lymph node metastases of <8 months and ≥8 months.
Figure 3
Figure 3
5-year OS rate of patients receiving any treatment and those receiving no treatment for lymph node metastasis.

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    1. Trovik C. S., Bauer H. C. F., Alvegård T. A., et al. Surgical margins, local recurrence and metastasis in soft tissue sarcomas: 559 surgically-treated patients from the Scandinavian sarcoma group register. European Journal of Cancer. 2000;36(6):710–716. doi: 10.1016/s0959-8049(99)00287-7. - DOI - PubMed
    1. Pisters P. W., Leung D. H., Woodruff J., Shi W., Brennan M. F. Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. Journal of Clinical Oncology. 1996;14(5):1679–1689. doi: 10.1200/jco.1996.14.5.1679. - DOI - PubMed
    1. Billingsley K. G., Burt M. E., Jara E., et al. Pulmonary metastases from soft tissue sarcoma: analysis of patterns of diseases and postmetastasis survival. Annals of Surgery. 1999;229(5):602–610. doi: 10.1097/00000658-199905000-00002. - DOI - PMC - PubMed
    1. Schur S., Hoetzenecker K., Lamm W., et al. Pulmonary metastasectomy for soft tissue sarcoma—report from a dual institution experience at the Medical University of Vienna. European Journal of Cancer. 2014;50(13):2289–2297. doi: 10.1016/j.ejca.2014.05.009. - DOI - PubMed
    1. Jablons D., Steinberg S. M., Roth J., Pittaluga S., Rosenberg S. A., Pass H. I. Metastasectomy for soft tissue sarcoma: further evidence for efficacy and prognostic indicators. The Journal of Thoracic and Cardiovascular Surgery. 1989;97(5):695–705. - PubMed