Epidermal growth factor receptor numbers in male and female mouse primary hepatocyte cultures

Cell Biochem Funct. 1988 Oct;6(4):231-5. doi: 10.1002/cbf.290060403.


Epidermal growth factor receptors (EGF-R) were measured in adult male and female mouse primary hepatocyte cultures. On culture day 1, female hepatocytes had significantly fewer EGF-R than male hepatocytes (1.3 x 10(4) versus 6.2 x 10(5) per cell). Over the next three days, morphological changes consistent with progressive heptocyte dedifferentiation were observed. During this period, EGF-R numbers progressively increased in female cultures and decreased in male cultures, and by day 4 the sexual difference in EGF-R numbers was obliterated. These results indicate that a relationship exists between the degree of differentiation in hepatocyte cultures and the expression of EGF-R on the cell surface.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cells, Cultured
  • ErbB Receptors / analysis*
  • ErbB Receptors / metabolism
  • Female
  • Liver / analysis*
  • Liver / cytology
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Sex Factors


  • ErbB Receptors