Ocular manifestations in celiac disease: an overview

Int Ophthalmol. 2020 Apr;40(4):1049-1054. doi: 10.1007/s10792-019-01254-x. Epub 2020 Jan 8.


Purpose: To review and highlight the ocular manifestations associated with celiac disease (CD) and presentation of their pathogenetic mechanisms.

Methods: A thorough review of the literature was performed using PubMed to identify articles about serrated polyposis syndrome. The search was performed using the search string: ("celiac disease" OR "coeliac disease") AND ("ocular manifestations" OR "eye" OR "orbitopathy" OR "uveitis" OR "neuro-ophthalmic manifestations"). Only articles in English were reviewed.

Results: Several ocular symptoms and disorders have been associated with CD and are a result of defective intestinal absorption and immunological mechanisms. These include nyctalopia, dry eye, cataract, thyroid-associated orbitopathy, uveitis, central retinal vein occlusion and neuro-ophthalmic manifestations. In addition, CD-related ocular disease may represent the first manifestation of CD.

Conclusion: CD may hold accountable for the development of ocular diseases of obscure etiology.

Keywords: Celiac disease; Dry eye; Extraintestinal manifestations; Eye; Uveitis.

Publication types

  • Review