Quality of life and functional independence in amyotrophic lateral sclerosis: A systematic review

Jéssica Paloma Rosa Silva; José Bomfim Santiago Júnior; Elizabete Lima Dos Santos; Fernanda Oliveira de Carvalho; Iandra Maria Pinheiro de França Costa; Deise Maria Furtado de Mendonça

doi:10.1016/j.neubiorev.2019.12.032

Quality of life and functional independence in amyotrophic lateral sclerosis: A systematic review

Neurosci Biobehav Rev. 2020 Apr:111:1-11. doi: 10.1016/j.neubiorev.2019.12.032. Epub 2020 Jan 7.

Authors

Jéssica Paloma Rosa Silva¹, José Bomfim Santiago Júnior², Elizabete Lima Dos Santos², Fernanda Oliveira de Carvalho³, Iandra Maria Pinheiro de França Costa⁴, Deise Maria Furtado de Mendonça⁵

Affiliations

¹ Department of Physical Therapy, Federal University of Sergipe, Lagarto, SE, Brazil; Laboratory of Neurobiology of Degenerative Diseases of the Nervous System, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
² Laboratory of Neurobiology of Degenerative Diseases of the Nervous System, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.
³ Department of Physical Therapy, Federal University of Sergipe, Lagarto, SE, Brazil; Health Sciences Post-Graduation Nucleus, Federal University of Sergipe, SE, Brazil.
⁴ Department of Physical Therapy, Federal University of Sergipe, Lagarto, SE, Brazil.
⁵ Laboratory of Neurobiology of Degenerative Diseases of the Nervous System, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil. Electronic address: deisemfmendonca@gmail.com.

PMID: 31917162
DOI: 10.1016/j.neubiorev.2019.12.032

Abstract

Amyotrophic Lateral Sclerosis (ALS) leads to functional capacity decline, generating great impact in quality of life. Quality of life is directly related to physical integrity and functional independence. This systematic review aimed to analyze treatment protocols and their outcomes from clinical trials with focus on ALS rehabilitation that evaluated the effects on quality of life and functional independence from their intervention process. A literature search was conducted through MEDLINE-PubMed, Science Direct, Web of Science and Scopus databases. A total of 3630 articles were identified. Eleven studies met the inclusion criteria. They focused on different aspects of quality of life or functional independence, which are: respiratory care, mental health, communication skills and exercises. Use of bipap and inspiratory muscle training, anxiety and depression, communication devices implementation and exercises safety and tolerability were considered as key points. However, the drastic evolution of the disease is a limiting factor to the perception of quality of life improvement by patients. Further studies should be done to validate the benefits on patients' quality of life.

Keywords: Motor neuron disease; Neurodegeneration; Neurodegenerative diseases; Rehabilitation.

Publication types

Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Activities of Daily Living*
Amyotrophic Lateral Sclerosis / physiopathology*
Amyotrophic Lateral Sclerosis / rehabilitation*
Humans
Quality of Life*
Severity of Illness Index*