Silencers, Enhancers, and the Multifunctional Regulatory Genome

Trends Genet. 2020 Mar;36(3):149-151. doi: 10.1016/j.tig.2019.12.005. Epub 2020 Jan 7.


Negative regulation of gene expression by transcriptional silencers has been difficult to study due to limited defined examples. A new study by Gisselbrecht et al. has dramatically increased the number of identified silencers and reveals that they are bifunctional regulatory sequences that also act as gene expression-promoting enhancers.

Publication types

  • Comment

MeSH terms

  • Animals
  • Drosophila*
  • Enhancer Elements, Genetic*