Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

doi:10.1186/s12986-019-0425-9

. 2020 Jan 6:17:1.

doi: 10.1186/s12986-019-0425-9. eCollection 2020.

Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

Chuyao Jin¹, Lizi Lin¹, Na Han², Zhiling Zhao², Zheng Liu¹, Shusheng Luo¹, Xiangrong Xu¹, Jue Liu³, Haijun Wang¹

Affiliations

¹ 1Department of Maternal and Child Health, School of Public Health, Peking University, No. 38 Xueyuan Rd, Haidian District, Beijing, 100191 People's Republic of China.
² Maternal and Child Health Hospital of Tongzhou District, Beijing, 101101 China.
³ 3Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No. 38 Xueyuan Rd, Haidian District, Beijing, 100191 People's Republic of China.

PMID: 31921323
PMCID: PMC6945716
DOI: 10.1186/s12986-019-0425-9

Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

Chuyao Jin et al. Nutr Metab (Lond). 2020.

. 2020 Jan 6:17:1.

doi: 10.1186/s12986-019-0425-9. eCollection 2020.

Authors

Chuyao Jin¹, Lizi Lin¹, Na Han², Zhiling Zhao², Zheng Liu¹, Shusheng Luo¹, Xiangrong Xu¹, Jue Liu³, Haijun Wang¹

Affiliations

¹ 1Department of Maternal and Child Health, School of Public Health, Peking University, No. 38 Xueyuan Rd, Haidian District, Beijing, 100191 People's Republic of China.
² Maternal and Child Health Hospital of Tongzhou District, Beijing, 101101 China.
³ 3Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No. 38 Xueyuan Rd, Haidian District, Beijing, 100191 People's Republic of China.

PMID: 31921323
PMCID: PMC6945716
DOI: 10.1186/s12986-019-0425-9

Abstract

Background: To assess the association between plasma retinol-binding protein 4 (RBP4) levels both in the first trimester and second trimester and risk of gestational diabetes mellitus (GDM).

Methods: Plasma RBP4 levels and insulin were measured among 135 GDM cases and 135 controls nested within the Peking University Birth Cohort in Tongzhou. Multivariable linear regression analysis was conducted to assess the influence of RBP4 levels on insulin resistance. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI) between RBP4 levels and risk of GDM.

Results: The GDM cases had significantly higher levels of RBP4 in the first trimester than controls (medians: 18.0 μg/L vs 14.4 μg/L; P < 0.05). Plasma RBP4 concentrations in the first and second trimester were associated with fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) in the second trimester (all P < 0.001). With adjustment for diet, physical activity, and other risk factors for GDM, the risk of GDM increased with every 1-log μg/L increment of RBP4 levels, and the OR (95% CI) was 3.12 (1.08-9.04) for RBP4 in the first trimester and 3.38 (1.03-11.08) for RBP4 in the second trimester.

Conclusions: Plasma RBP4 levels both in the first trimester and second trimester were dose-dependently associated with increased risk of GDM.

Keywords: Gestational diabetes mellitus; Insulin resistance; Retinol-binding protein 4.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

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References

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1. Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354:2552–2563. doi: 10.1056/NEJMoa054862. - DOI - PubMed
1. Sun L, Qi Q, Zong G, Ye X, Li H, Liu X, et al. Elevated plasma retinol-binding protein 4 is associated with increased risk of type 2 diabetes in middle-aged and elderly Chinese adults. J Nutr. 2014;144:722–728. doi: 10.3945/jn.113.189860. - DOI - PubMed
1. Johns EC, Denison FC, Norman JE, Reynolds RM. Gestational diabetes mellitus: mechanisms, treatment, and complications. Trends Endocrinol Metab. 2018;29:743–754. doi: 10.1016/j.tem.2018.09.004. - DOI - PubMed

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[1] Quadro L, Hamberger L, Colantuoni V, Gottesman ME, Blaner WS. Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models. Mol Asp Med. 2003;24:421–430. doi: 10.1016/S0098-2997(03)00038-4. - DOI - PubMed

[2] Quadro L, Hamberger L, Colantuoni V, Gottesman ME, Blaner WS. Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models. Mol Asp Med. 2003;24:421–430. doi: 10.1016/S0098-2997(03)00038-4. - DOI - PubMed

[3] Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356–362. doi: 10.1038/nature03711. - DOI - PubMed

[4] Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356–362. doi: 10.1038/nature03711. - DOI - PubMed

[5] Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354:2552–2563. doi: 10.1056/NEJMoa054862. - DOI - PubMed

[6] Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354:2552–2563. doi: 10.1056/NEJMoa054862. - DOI - PubMed

[7] Sun L, Qi Q, Zong G, Ye X, Li H, Liu X, et al. Elevated plasma retinol-binding protein 4 is associated with increased risk of type 2 diabetes in middle-aged and elderly Chinese adults. J Nutr. 2014;144:722–728. doi: 10.3945/jn.113.189860. - DOI - PubMed

[8] Sun L, Qi Q, Zong G, Ye X, Li H, Liu X, et al. Elevated plasma retinol-binding protein 4 is associated with increased risk of type 2 diabetes in middle-aged and elderly Chinese adults. J Nutr. 2014;144:722–728. doi: 10.3945/jn.113.189860. - DOI - PubMed

[9] Johns EC, Denison FC, Norman JE, Reynolds RM. Gestational diabetes mellitus: mechanisms, treatment, and complications. Trends Endocrinol Metab. 2018;29:743–754. doi: 10.1016/j.tem.2018.09.004. - DOI - PubMed

[10] Johns EC, Denison FC, Norman JE, Reynolds RM. Gestational diabetes mellitus: mechanisms, treatment, and complications. Trends Endocrinol Metab. 2018;29:743–754. doi: 10.1016/j.tem.2018.09.004. - DOI - PubMed

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Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

Affiliations

Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

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