Protein regulator of cytokinesis‑1 (PRC1) is a microtubule‑associated factor involved in cytokinesis. Recent studies have indicated that PRC1 overexpression is involved in tumorigenesis in multiple types of human cancer. However, the expression, biological functions and the prognostic significance of PRC1 in ovarian cancer have not yet been clarified. In this study, it was confirmed that the PRC1 mRNA and protein expression levels were upregulated in high‑grade serous ovarian carcinoma (HGSOC) tissues, particularly in patients without breast cancer susceptibility gene (BRCA) pathogenic mutations. PRC1 overexpression contributed to drug resistance, tumor recurrence and a poor prognosis. The findings also indicated that PRC1 knockdown decreased the proliferation, metastasis and multidrug resistance of ovarian cancer cells in vitro. It was also demonstrated that forkhead box protein M1 (FOXM1) regulated the mRNA and protein expression of PRC1. Dual‑luciferase reporter assay and rescue assay confirmed that PRC1 was a direct crucial downstream target of FOXM1. On the whole, the findings of this study confirmed that PRC1 was a major prognostic factor of HGSOC and a promising therapeutic biomarker for the treatment of ovarian cancer.
FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients.J Exp Clin Cancer Res. 2017 May 8;36(1):63. doi: 10.1186/s13046-017-0536-y. J Exp Clin Cancer Res. 2017. PMID: 28482906 Free PMC article.
PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway.Mol Cancer. 2017 Jun 24;16(1):108. doi: 10.1186/s12943-017-0682-z. Mol Cancer. 2017. PMID: 28646916 Free PMC article.
Protein regulator of cytokinesis-1 expression: prognostic value in lung squamous cell carcinoma patients.J Thorac Dis. 2017 Jul;9(7):2054-2060. doi: 10.21037/jtd.2017.06.91. J Thorac Dis. 2017. PMID: 28840006 Free PMC article.
FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy.Adv Cancer Res. 2013;119:191-419. doi: 10.1016/B978-0-12-407190-2.00016-2. Adv Cancer Res. 2013. PMID: 23870513 Review.
Prognostic value of FOXM1 in solid tumors: a systematic review and meta-analysis.Oncotarget. 2017 May 9;8(19):32298-32308. doi: 10.18632/oncotarget.15764. Oncotarget. 2017. PMID: 28427178 Free PMC article. Review.