Human serum antibodies reactive with dietary proteins. IgG subclass distribution

Int Arch Allergy Appl Immunol. 1988;87(2):184-8. doi: 10.1159/000234670.


The isotype distribution of human IgG antibodies reactive with common dietary proteins has been evaluated in sera from adult patients with the irritable bowel syndrome and with bronchial asthma using a solid-phase immunoassay (ELISA). In both these medical disorders, serum antibodies reactive with ovalbumin or gliadin were restricted predominantly to the IgG4 isotype; however, IgG antibodies reactive with bovine milk antigens, notably casein, were often restricted to both the IgG2 and IgG4 isotypes. A similar serum IgG antibody isotype distribution for these dietary protein antigens was also demonstrated in IgG antibody-positive healthy adults. These data amplify the view that production of antibodies of the IgG4 isotype may reflect a normal immune response to dietary protein antigens presented at mucosal surfaces.

MeSH terms

  • Adult
  • Antibody Specificity
  • Antigen-Antibody Reactions*
  • Asthma / immunology
  • Colonic Diseases, Functional / immunology
  • Dietary Proteins / immunology*
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin G / classification*
  • Immunoglobulin Isotypes / analysis
  • Milk Proteins / immunology


  • Dietary Proteins
  • Immunoglobulin G
  • Immunoglobulin Isotypes
  • Milk Proteins