Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum

Sridharan Balu; Selvakumar Palanisamy; Vijaylakshmi Velusamy; Thomas C K Yang; El-Said I El-Shafey

doi:10.1016/j.msec.2019.110367

Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum

Mater Sci Eng C Mater Biol Appl. 2020 Mar:108:110367. doi: 10.1016/j.msec.2019.110367. Epub 2019 Nov 1.

Authors

Sridharan Balu¹, Selvakumar Palanisamy², Vijaylakshmi Velusamy³, Thomas C K Yang⁴, El-Said I El-Shafey⁵

Affiliations

¹ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei City, Taiwan.
² Precision and Materials Research Centre, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei City, Taiwan; Division of Electrical and Electronic Engineering, School of Engineering, Manchester Metropolitan University, Chester Street, Manchester, M1 5GD, United Kingdom. Electronic address: prmselva@gmail.com.
³ Division of Electrical and Electronic Engineering, School of Engineering, Manchester Metropolitan University, Chester Street, Manchester, M1 5GD, United Kingdom. Electronic address: V.Velusamy@mmu.ac.uk.
⁴ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei City, Taiwan; Precision and Materials Research Centre, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei City, Taiwan. Electronic address: ckyang@mail.ntut.edu.tw.
⁵ Chemistry Department, College of Science, Sultan Qaboos University, P.O. Box 36, Postal Code Al-Khoudh, 123, Muscat, Oman.

PMID: 31923993
DOI: 10.1016/j.msec.2019.110367

Abstract

In the present work describes a facile synthesis of tin disulfide (SnS₂) nanorods decorated graphene-β-cyclodextrin (SnS₂/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS₂/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS₂/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS₂, and SnS₂/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS₂-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01-150.76 μM. The detection limit of the biosensor was 4 nM. The SnS₂/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM^-1 cm^-2) along with reusability for detection of DA. The fabricated SnS₂/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.

Keywords: Biosensor; Dopamine; Graphene nanocomposite; Guest-host chemistry; SnS(2) nanorods; Sonochemical method.

MeSH terms

Animals
Biosensing Techniques
Brain / metabolism*
Disulfides / chemistry*
Dopamine / blood*
Electrochemical Techniques
Graphite / chemistry*
Humans
Limit of Detection
Nanocomposites / chemistry*
Nanotubes / chemistry*
Nanotubes / ultrastructure
Oxidation-Reduction
Rats
Tin / chemistry*
X-Ray Diffraction
beta-Cyclodextrins / chemistry*

Substances

Disulfides
beta-Cyclodextrins
Tin
Graphite
betadex
Dopamine