Treating sickle cell anemia: A new era dawns

Am J Hematol. 2020 Apr;95(4):338-342. doi: 10.1002/ajh.25724. Epub 2020 Jan 21.
No abstract available

MeSH terms

  • Anemia, Sickle Cell / complications
  • Anemia, Sickle Cell / drug therapy
  • Anemia, Sickle Cell / physiopathology
  • Anemia, Sickle Cell / therapy*
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Benzaldehydes / therapeutic use
  • Child
  • Fetal Hemoglobin / biosynthesis
  • Fetal Hemoglobin / genetics
  • Forecasting
  • Gene Expression Regulation / drug effects
  • Genetic Therapy
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Hydroxyurea / pharmacology
  • Hydroxyurea / therapeutic use
  • Hypoxia, Brain / prevention & control
  • Infant
  • P-Selectin / antagonists & inhibitors
  • Pain / prevention & control
  • Pyrazines / therapeutic use
  • Pyrazoles / therapeutic use
  • Therapies, Investigational / methods*

Substances

  • Antibodies, Monoclonal, Humanized
  • Benzaldehydes
  • P-Selectin
  • Pyrazines
  • Pyrazoles
  • voxelotor
  • Fetal Hemoglobin
  • crizanlizumab
  • Hydroxyurea