Sulfogalactolipid binding protein SLIP 1: a conserved function for a conserved protein

J Cell Physiol. 1988 Dec;137(3):462-8. doi: 10.1002/jcp.1041370310.

Abstract

We have studied the species and tissue expression of the 68kD sulfogalactolipid binding protein SLIP 1, originally detected in the male germ cells of the rat (Lingwood: Can. J. Biochem. Cell Biol., 63:1077-1085, 1985). Our results show that SLIP 1 has been highly conserved during evolution and is found in the testes of all vertebrates tested. In studies in the rat, we have found that SLIP 1 is, however, tissue restricted, being found only in the brain (also a major site of sulfogalactolipid biosynthesis) in addition to the testis. SLIP 1 was also detected in mammalian oocytes. The SLIP 1 species detected in brain and oocytes retain the sulfogalactolipid-binding characteristics of rat testicular SLIP 1, indicating that, in addition to immunological features, the glycolipid-binding function of SLIP 1 is conserved in these tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Evolution
  • Brain Chemistry
  • Carrier Proteins / analysis*
  • Carrier Proteins / metabolism
  • Cell Cycle Proteins
  • Female
  • Glycolipids / metabolism*
  • Humans
  • Male
  • Membrane Proteins / analysis*
  • Membrane Proteins / metabolism
  • Oocytes / analysis
  • RNA-Binding Proteins
  • Rats
  • Rats, Inbred Strains
  • Testis / analysis*
  • Vertebrates / metabolism*

Substances

  • Carrier Proteins
  • Cell Cycle Proteins
  • Glycolipids
  • MIF4GD protein, human
  • Membrane Proteins
  • RNA-Binding Proteins
  • Slip1 protein, rat