The effect of fibromyalgia treatment on tinnitus

Am J Otolaryngol. 2020 May-Jun;41(3):102390. doi: 10.1016/j.amjoto.2020.102390. Epub 2020 Jan 3.


Objectives: We investigated the frequency of tinnitus in fibromyalgia patients and the effect of drugs used for routine fibromyalgia on tinnitus.

Methods: We included 101 diagnosed fibromyalgia patients. After detailed ear nose throat examination, audiometric tests and tinnitus handicap index (THI) were performed. After the tests, routine treatment for fibromyalgia was started by the physical therapy and rehabilitation department. Two months after the beginning of the treatment, THI were repeated again and the results were statistically evaluated.

Results: All patients included in the study were women. 74.3% of the patients had tinnitus. Pregabalin and selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant-treated patients were evaluated; In both groups, there was a statistically significant difference between pre- and post-treatment tinnitus levels (p < .001). However, there was no statistically significant difference between pregabalin group and diloxetine group according to treatment results.

Conclusions: The incidence of tinnitus is high in fibromyalgia patients. That pregabalin and duloxetine agents routinely used in fibromyalgia require further experimental and human studies in order to be able to use in tinnitus.

Keywords: Fibromyalgia; Pregabalin; SSRI; Tinnitus.

MeSH terms

  • Adult
  • Aged
  • Antidepressive Agents / therapeutic use*
  • Duloxetine Hydrochloride / therapeutic use*
  • Female
  • Fibromyalgia / drug therapy*
  • Fibromyalgia / etiology*
  • Fibromyalgia / therapy
  • Humans
  • Middle Aged
  • Physical Therapy Modalities
  • Pregabalin / therapeutic use*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Tinnitus / diagnosis
  • Tinnitus / drug therapy*
  • Tinnitus / etiology*
  • Young Adult


  • Antidepressive Agents
  • Serotonin Uptake Inhibitors
  • Pregabalin
  • Duloxetine Hydrochloride