New antibiotics for the treatment of infections by multidrug-resistant microorganisms

Abstract

One of the current priorities of the World Health Organization is multidrug-resistant bacteria, because they are a global problem due to their rapid spread and the difficulty of their treatment. In addition, they are associated with high morbidity, mortality and high economic costs. There are multidrug-resistant bacteria, both Gram-positive and Gram-negative, including Pseudomonas aeruginosa and Acinetobacter baumannii resistant to carbapenems, enterobacteria producing carbapenemases, Staphylococcus aureus resistant to methicillin and/or with intermediate sensitivity to vancomycin, and Enterococcus faecium (and less frequently Enterococcus faecalis) resistant to vancomycin. This review will comment on the new antibiotics that have been incorporated into the therapeutic arsenal in recent years, as well as other promising antibiotics that are in their final stages of development.

Keywords: Antimicrobial agents; Antimicrobianos; Bacterias multirresistentes; Gram-negative bacteria; Gram-positive bacteria; Gramnegativos; Grampositivos; Multidrug-resistant bacteria; Terapéutica; Therapeutic.