Humanized mice as preclinical models for myeloid malignancies

Rana Gbyli; Yuanbin Song; Stephanie Halene

doi:10.1016/j.bcp.2020.113794

Humanized mice as preclinical models for myeloid malignancies

Biochem Pharmacol. 2020 Apr:174:113794. doi: 10.1016/j.bcp.2020.113794. Epub 2020 Jan 10.

Authors

Rana Gbyli¹, Yuanbin Song¹, Stephanie Halene²

Affiliations

¹ Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT, USA.
² Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT, USA. Electronic address: stephanie.halene@yale.edu.

PMID: 31926939
DOI: 10.1016/j.bcp.2020.113794

Abstract

Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been placed to advance and optimize humanized mice to support the engraftment, differentiation, and maintenance of hematopoietic stem cells (HSCs) and the human hematological system in order to broaden the scope of applications of such models. This review covers the background of humanized mice, how they are used as platforms to model myeloid malignancies, and the various current and potential approaches to further enhance their utilization in biomedical research.

Keywords: Cytokine humanization; Humanized mice; Immunodeficient mouse models; Myeloid malignancy; Pre-clinical studies; Xenotransplantation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Disease Models, Animal*
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells / pathology
Heterografts
Humans
Leukemia, Myeloid, Acute / pathology*
Mice
Mice, Inbred NOD
Mice, SCID
Myelodysplastic Syndromes / pathology*