[Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomers (Endotelon)]

J Fr Ophtalmol. 1988;11(5):453-60.
[Article in French]


Light vision is a major element of the visual function. However, it varies from one subject to another. Many factors may modify it in the absence of amy retinal pathology (âge, fatigue, stress). A lower resistance to glare and an alteration of scotopic vision are often mentioned during medical visits. We endeavored to obtain a protection with Endotelon in subjects presenting no major retinal or ophthalmological pathology. Endotelon comes in tablets of 50 mg of procyanidolic oligomers. This compound of vegetal origin (from grape seeds) belongs to the chemical class of flavones which selectively fix on collagen and elastin fibers, thus reinforcing the structure of the vascular connective tissue. The drug efficiency on the resistance to glare and on the night morphoscopic vision was demonstrated by means of three tests: Comberg's nyctometer, Beyne's lantern and ergovision. One hundred subjects were tested in two center. In both center, a treated group received 4 tablets of Endotelon a day for five weeks and a control group received no treatment. Two patients stopped the experiment. Nyctometer: the improvement in the visual performances after glare as well as the rapidity with which these results were obtained is very significant compared to the results obtained by the control group. Visual adaptation to low luminances is also improved under treatment. Ergovision tests were performed in two light environments: a standard one and glare. These results support the previous ones. There is a narrow correlation between the decrease in visual performances after a quick retinal glare and the increase in the environmental luminance at the time of inclusion.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antihypertensive Agents / therapeutic use*
  • Biflavonoids*
  • Catechin / analogs & derivatives*
  • Catechin / therapeutic use
  • Choroid / blood supply*
  • Female
  • Humans
  • Male
  • Photic Stimulation
  • Proanthocyanidins*
  • Retinal Vessels*
  • Time Factors
  • Vision Tests
  • Vision, Ocular / drug effects*
  • Vision, Ocular / physiology


  • Antihypertensive Agents
  • Biflavonoids
  • Proanthocyanidins
  • procyanidin
  • procyanidol oligomer
  • Catechin