The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis

Psychiatry Res. 2020 Feb:284:112749. doi: 10.1016/j.psychres.2020.112749. Epub 2020 Jan 2.

Abstract

The current meta-analysis examined the effects of psilocybin in combination with behavioral interventions on anxiety and depression in samples with elevated symptoms. Across four studies (one uncontrolled; three randomized, placebo-controlled; N = 117), within-group pre-post and pre-follow-up effects on anxiety and depression were large (Hedges' gs=1.16 to 1.47) and statistically significant. Across three placebo-controlled studies, pre-post placebo-controlled effects were also large (gs = 0.82 to 0.83) and statistically significant. No serious adverse events were reported. Limitations include the small number of studies and risk for bias within studies. Results tentatively support future research on psilocybin for the treatment of anxiety and depression.

Keywords: Anxiety; Depression; Psilocybin.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Anxiety / drug therapy*
  • Depression / drug therapy*
  • Female
  • Humans
  • Male
  • Psilocybin / therapeutic use*
  • Randomized Controlled Trials as Topic
  • Treatment Outcome

Substances

  • Psilocybin