Relationship of depth of brain lesions to consciousness and outcome after closed head injury

J Neurosurg. 1988 Dec;69(6):861-6. doi: 10.3171/jns.1988.69.6.0861.


Magnetic resonance (MR) imaging was performed in 94 patients who sustained closed head injury of varying severity. Results of MR studies obtained after the intensive care phase of treatment disclosed that intracranial lesions were present in about 88% of the patients. Consistent with the centripetal model of progressive brain injury proposed in 1974 by Ommaya and Gennarelli, the depth of brain lesion was positively related to the degree and duration of impaired consciousness. Further analysis indicated that the relationship between depth of brain lesion and impaired consciousness could not be attributed to secondary effects of raised intracranial pressure or to the size of intracranial lesion(s).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Amnesia / etiology
  • Brain / pathology*
  • Cerebral Ventricles / pathology
  • Consciousness*
  • Craniocerebral Trauma / complications
  • Craniocerebral Trauma / pathology*
  • Craniocerebral Trauma / physiopathology
  • Disability Evaluation
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Time Factors