Osteopontin expression is associated with progression and adverse prognosis in patients with resectable gastrointestinal stromal tumor

Jinhai Wang; Xiaobin Cheng; Sen Lu; Weina Fan

Osteopontin expression is associated with progression and adverse prognosis in patients with resectable gastrointestinal stromal tumor

Int J Clin Exp Pathol. 2019 Apr 1;12(4):1385-1390. eCollection 2019.

Authors

Jinhai Wang¹, Xiaobin Cheng¹, Sen Lu¹, Weina Fan²

Affiliations

¹ Department of Colorectal Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, P. R. China.
² Department of Intensive Care Unit, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, P. R. China.

PMID: 31933953
PMCID: PMC6947051

Abstract

Objectives: Osteopontin (OPN) is reported to be particularly associated with the progression of several human malignancies. This study was designed to examine the clinicopathologic significance of OPN in gastrointestinal stromal tumor (GISTs).

Methods: The level of OPN expression in a large cohort of resectable GISTs was evaluated with immunohistochemistry. Its correlation with the clinicopathologic parameters of patients with resectable GISTs was analyzed. A survival analysis was performed to evaluate the prognostic significance of OPN expression using the Kaplan-Meier method.

Results: In 108 patients with resectable GISTs, the most high-risk GISTs had a strong level of OPN expression. Strong OPN expression was also significantly associated with tumor size, mitosis, and recurrence, but not gender and age. Patients with weak OPN expression had a relatively longer disease-free survival compared to patients with strong OPN expression.

Conclusions: OPN expression is a putative marker for tumor progression and an adverse prognosis in GISTs.

Keywords: Osteopontin; gastrointestinal stromal tumors; immunohistochemistry; prognosis.