Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Dec 9:2019:3786245.
doi: 10.1155/2019/3786245. eCollection 2019.

Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF?

Asterios Kampouras  1 , Elpis Hatziagorou  1 , Vasiliki Avramidou  1 , Vasiliki Georgopoulou  2 , Fotios Kirvassilis  1 , John Tsanakas  1
Affiliations
Free PMC article

Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF?

Asterios Kampouras et al. Pulm Med. .
Free PMC article

Abstract

Introduction: Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients.

Aim: To evaluate whether Pseudomonas aeruginosa colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomography (HRCT) indices among patients with CF; to check if Pseudomonas colonization can predict exercise intolerance.

Subjects: Seventy-eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit.

Results: 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO2 peak: 79.1%) were evaluated: 33 were chronically colonized with Pseudomonas aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO2 peak% (p < 0.001), LCI (p < 0.001), as well as FEV1% (p < 0.001) and FVC% (p < 0.001). Pseudomonas colonization could predict VO2 peak% (p < 0.001, r 2: -0.395).

Conclusion: Exercise capacity as reflected by peak oxygen uptake is reduced in Pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients.

PubMed Disclaimer

Conflict of interest statement

All authors would like to confirm that there is nothing to declare.

Figures

Figure 1
Figure 1
FEV1% predicted among the three groups of patients. (0: patients not colonized, 1: patients intermittently colonized with P. aeruginosa, 2: patients chronically colonized with P. aeruginosa).
Figure 2
Figure 2
LCI among the three groups of patients. (0: patients not colonized, 1: patients intermittently colonized with P. aeruginosa, 2: patients chronically colonized with P. aeruginosa).
Figure 3
Figure 3
VO2 peak% predicted among patients not colonized, intermittently and chronically colonized with Pseudomonas aeruginosa. (0: patients not colonized, 1: patients intermittently colonized with P. aeruginosa, 2: patients chronically colonized with P. aeruginosa).
Figure 4
Figure 4
Bhalla scores among patients not colonized, intermittently and chronically colonized with Pseudomonas aeruginosa. (0: patients not colonized, 1: patients intermittently colonized with P. aeruginosa, 2: patients chronically colonized with P. aeruginosa.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Davies J. C., Alton E. W., Bush A. Cystic fibrosis. BMJ. 2007;335(7632):1255–1259. doi: 10.1136/bmj.39391.713229.AD. 2007–12-13 23:01:06. - DOI - PMC - PubMed
    1. Tomashefski J. F., Jr., Abramowsky C. R. The pathology of cystic fibrosis. In: Davis P. B., editor. Cystic Fibrosis. New York: Marcel Dekker Inc; 1993.
    1. Gibson R. L. B. J., Ramsey B. W. Pathophysiology and management of pulmonary infections in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 2003;168(8):918–951. doi: 10.1164/rccm.200304-505so. - DOI - PubMed
    1. Kerem E., Viviani L., Zolin A., et al. Factors associated with FEV1 decline in cystic fibrosis: analysis of the ECFS patient registry. European Respiratory Journal. 2014;43(1):125–133. doi: 10.1183/09031936.00166412. - DOI - PubMed
    1. Nixon P. A., Orenstein D. M., Kelsey S. F., Doershuk C. F. The prognostic value of exercise testing in patients with cystic fibrosis. New England Journal of Medicine. 1992;327(25):1785–1788. doi: 10.1056/nejm199212173272504. - DOI - PubMed