Effect of an anti-ulcer drug, plaunotol, and its metabolites on NAD+ dependent 15-hydroxyprostaglandin dehydrogenase from gastric mucosa

Life Sci. 1988;43(20):1647-52. doi: 10.1016/0024-3205(88)90537-1.


15-Hydroxyprostaglandin dehydrogenase was partially purified from hog gastric mucosa by about 1000-fold with a 13.5% yield. Its molecular weight was estimated to be 32,000 daltons by gel filtration. The enzyme was inhibited by some metabolites of plaunotol [(2E, 6Z, 10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetrae n-1- ol], a new anti-ulcer drug. The inhibition patterns for substrates, prostaglandin E1 and NAD+ were both uncompetitive with Ki values of 7.8 and 19.7 microM, respectively.

MeSH terms

  • Animals
  • Anti-Ulcer Agents / pharmacology*
  • Diterpenes
  • Fatty Alcohols / pharmacology*
  • Gastric Mucosa / enzymology*
  • Hydroxyprostaglandin Dehydrogenases / antagonists & inhibitors*
  • Hydroxyprostaglandin Dehydrogenases / isolation & purification
  • Kinetics
  • Structure-Activity Relationship
  • Swine


  • Anti-Ulcer Agents
  • Diterpenes
  • Fatty Alcohols
  • Hydroxyprostaglandin Dehydrogenases
  • 15-hydroxyprostaglandin dehydrogenase
  • plaunotol