Current and Alternative Therapies for Nasal Mucosa Injury: A Review

Int J Mol Sci. 2020 Jan 12;21(2):480. doi: 10.3390/ijms21020480.


Nasal mucosa injury can be caused by trauma, radiotherapy, chronic infection such as sinusitis, and post sinus surgery. The rate of healing and its treatment are important in the recovery of patients especially in post sinus surgery, which introduces new injuries. In this review, the current knowledge in terms of the mechanism underlying nasal wound healing was initially discussed. The currently available treatment options for enhancement of wound healing following sinus surgery were discussed and these had included intravenous antibiotics or steroids, various nasal sprays, and nasal packing. In addition, emerging alternative therapies in nasal mucosa wound healing such as herbal medicine and the advancement of regenerative medicine therapies such as stem cells and their byproducts were also discussed. Despite the various available treatment options for wound healing in nasal mucosa, rigorous strong evidence of their efficacy is gravely warranted in order to recommend them as part of the treatment modality.

Keywords: nasal injury; nasal mucosa; regenerative medicine; wound healing.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Anti-Bacterial Agents / therapeutic use
  • Complementary Therapies
  • Endoscopy / adverse effects
  • Humans
  • Nasal Mucosa / drug effects
  • Nasal Mucosa / injuries*
  • Nasal Sprays
  • Paranasal Sinus Diseases / surgery*
  • Postoperative Complications / drug therapy*
  • Steroids / therapeutic use
  • Wound Healing / drug effects


  • Anti-Bacterial Agents
  • Nasal Sprays
  • Steroids