Chest Computed Tomography Abnormalities and Their Relationship to the Clinical Manifestation of Respiratory Syncytial Virus Infection in a Genetically Confirmed Outbreak

Intern Med. 2020;59(2):247-252. doi: 10.2169/internalmedicine.3117-19. Epub 2020 Jan 15.

Abstract

Studies reporting chest images of respiratory syncytial virus (RSV)-induced lower respiratory tract infection (LRTI) in an outbreak setting and their relationship to the clinical manifestation are limited. During a genetically confirmed RSV outbreak, eight patients underwent both chest X-ray and computed tomography (CT). Among these, 5 cases had newly appearing abnormalities on CT, although chest X-ray was able to detect abnormalities in only 2 cases (40%). Although bronchial wall thickening was common, other findings and their distribution were variable, even in an outbreak setting. All patients with both a history of anticancer chemotherapy against hematological cancer and lower respiratory symptoms, such as wheezing, sputum, and hypoxemia, had abnormalities on CT, suggesting that these two factors might be important for predicting the existence of LRTI in RSV-infected patients.

Keywords: bronchial wall thickenings; chest CT; lower respiratory tract infection; outbreak; respiratory syncytial virus.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Disease Outbreaks
  • Humans
  • Japan / epidemiology
  • Middle Aged
  • Respiratory Sounds
  • Respiratory Syncytial Virus Infections / diagnostic imaging*
  • Respiratory Syncytial Virus Infections / epidemiology
  • Respiratory Tract Infections / diagnostic imaging*
  • Respiratory Tract Infections / epidemiology
  • Retrospective Studies
  • Tomography, X-Ray Computed / methods
  • Young Adult