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, 1 (2), 197-203

Melatonin and Age-Related Cardiovascular Diseases


Melatonin and Age-Related Cardiovascular Diseases

Jiayu Zhong et al. Aging Med (Milton).


The pineal gland is a neuroendocrine gland closely related to human aging. Melatonin is a kind of indole neuroendocrine hormone secreted by the pineal gland, which is essential for maintaining physiological function. Many researches found that melatonin plays a key role in anti-aging-related cardiovascular diseases. In this paper, the latest advances in the study of melatonin and aging-related cardiovascular diseases are reviewed, and their related physiological functions and mechanisms are discussed.

Keywords: aging; cardiovascular diseases; melatonin; pineal gland.

Conflict of interest statement

The authors declare no conflict of interest.

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    1. Grosso G, Estruch R. Nut consumption and age‐related disease. Maturitas. 2016;84:11‐16. - PubMed
    1. Pierpaoli W, Maestroni GJ. Melatonin: a principal neuroimmunoregulatory and anti‐stress hormone: its anti‐aging effects. Immunol Lett. 1987;16(3–4):355‐361. - PubMed
    1. Malm OJ, Skaug OE, Lingjaerde P. The effect of pinealectomy on bodily growth, survival rate and P32 uptake in the rat. Acta Endocrinol. 1959;30(1):22‐28. - PubMed
    1. Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011;51(1):1‐16. - PubMed
    1. Dubbels R, Reiter RJ, Klenke E, et al. Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography‐mass spectrometry. J Pineal Res. 1995;18(1):28‐31. - PubMed

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