[Risk factors for cow's milk protein allergy in infants: a multicenter survey]

Zhongguo Dang Dai Er Ke Za Zhi. 2020 Jan;22(1):42-46. doi: 10.7499/j.issn.1008-8830.2020.01.009.
[Article in Chinese]


Objective: To investigate the risk factors for cow's milk protein allergy (CMPA) among infants through a multicenter clinical study.

Methods: A total of 1 829 infants, aged 1-12 months, who attended the outpatient service of the pediatric department in six hospitals in Shenzhen, China from June 2016 to May 2017 were enrolled as subjects. A questionnaire survey was performed to screen out suspected cases of CMPA. Food avoidance and oral food challenge tests were used to make a confirmed diagnosis of CMPA CMPA. A multivariate logistic regression analysis was used to investigate the risk factors for CMPA.

Results: Among the 1 829 infants, 82 (4.48%) were diagnosed with CMPA. The multivariate logistic regression analysis showed that maternal food allergy (OR=4.91, 95%CI: 2.24-10.76, P<0.05), antibiotic exposure during pregnancy (OR=3.18, 95%CI: 1.32-7.65, P<0.05), and the introduction of complementary food at an age of <4 months (OR=3.55, 95%CI: 1.52-8.27, P<0.05) were risk factors for CMPA, while exclusive breastfeeding (OR=0.21, 95%CI: 0.08-0.58, P<0.05) and the introduction of complementary food at an age of >6 months (OR=0.38, 95%CI: 0.17-0.86, P<0.05) were protective factors.

Conclusions: The introduction of complementary food at an age of <4 months, maternal food allergy, and antibiotic exposure during pregnancy are risk factors for CMPA in infants.

目的: 通过多中心临床研究了解婴儿牛奶蛋白过敏(CMPA)发生的危险因素。

方法: 以2016年6月至2017年5月于深圳市6家医院儿科门诊就诊的1 829例1~12月龄婴儿为调查对象,通过问卷调查,筛选CMPA可疑病例,然后进行食物回避激发试验以确诊CMPA。采用多因素logistic回归分析调查婴儿CMPA发生的危险因素。

结果: 1 829例患儿中,82例确诊为CMPA(4.48%)。多因素logistic回归分析显示,母亲食物过敏(OR=4.91,95% CI:2.24~10.76)、母亲孕期使用抗生素(OR=3.18,95% CI:1.32~7.65)、开始添加辅食月龄小于 < 4个月(OR=3.55,95% CI:1.52~8.27)是CMPA的独立危险因素(P < 0.05),而纯母乳喂养(OR=0.21,95% CI:0.08~0.58)和> 6个月添加辅食(OR=0.38,95% CI:0.17~0.86)是CMPA的保护因素(P < 0.05)。

结论: 小于4月龄添加辅食、母亲食物过敏、母孕期使用抗生素是婴儿CMPA发生的危险因素。

MeSH terms

  • Animals
  • Cattle
  • China
  • Female
  • Humans
  • Infant
  • Milk Hypersensitivity*
  • Milk Proteins
  • Pregnancy
  • Risk Factors
  • Surveys and Questionnaires


  • Milk Proteins

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