Resolution of inflammation in periodontitis: a review
- PMID: 31949825
- PMCID: PMC6962983
Resolution of inflammation in periodontitis: a review
Abstract
Inflammation is a physiological response to an injury or infection. It is supposed to be self-limiting, stopping when the situation recovers to normal to protect the tissue. This self-limiting action is called "resolution of inflammation". Currently, periodontitis is thought to be the result of failed resolution of inflammation; specifically, it is the result of excessive inflammation that leads to gingival recession and alveolar bone loss. In this review, we will focus on the processes of resolution of inflammation in periodontitis, which may be a therapeutic target of periodontitis.
Keywords: Periodontitis; inflammation; resolution; self-limited.
IJCEP Copyright © 2018.
Conflict of interest statement
None.
Similar articles
-
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.J Periodontol. 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. J Periodontol. 2018. PMID: 29926944
-
Regenerative effect of azithromycin on periodontitis with different levels of gingival inflammation: three case reports.Aust Dent J. 2014 Jun;59(2):245-51. doi: 10.1111/adj.12177. Aust Dent J. 2014. PMID: 24861402
-
Extracellular ATP is a key modulator of alveolar bone loss in periodontitis.Arch Oral Biol. 2017 Sep;81:131-135. doi: 10.1016/j.archoralbio.2017.05.002. Epub 2017 May 13. Arch Oral Biol. 2017. PMID: 28528307 Review.
-
Ac45 silencing mediated by AAV-sh-Ac45-RNAi prevents both bone loss and inflammation caused by periodontitis.J Clin Periodontol. 2015 Jul;42(7):599-608. doi: 10.1111/jcpe.12415. Epub 2015 Jun 11. J Clin Periodontol. 2015. PMID: 25952706 Free PMC article.
-
Dental plaque-induced gingival conditions.J Clin Periodontol. 2018 Jun;45 Suppl 20:S17-S27. doi: 10.1111/jcpe.12937. J Clin Periodontol. 2018. PMID: 29926503 Review.
Cited by
-
6-(Methylsulfinyl) Hexyl Isothiocyanate Inhibits IL-6 and CXCL10 Production in TNF-α-Stimulated Human Oral Epithelial Cells.Curr Issues Mol Biol. 2022 Jun 29;44(7):2915-2922. doi: 10.3390/cimb44070201. Curr Issues Mol Biol. 2022. PMID: 35877425 Free PMC article.
-
The Anti-Inflammatory Effects of Iberin on TNF-α-Stimulated Human Oral Epithelial Cells: In Vitro Research.Biomedicines. 2022 Dec 6;10(12):3155. doi: 10.3390/biomedicines10123155. Biomedicines. 2022. PMID: 36551911 Free PMC article.
-
CD301b+ macrophage: the new booster for activating bone regeneration in periodontitis treatment.Int J Oral Sci. 2023 May 17;15(1):19. doi: 10.1038/s41368-023-00225-4. Int J Oral Sci. 2023. PMID: 37198150 Free PMC article.
-
Recent Advances in Apical Periodontitis Treatment: A Narrative Review.Bioengineering (Basel). 2023 Apr 19;10(4):488. doi: 10.3390/bioengineering10040488. Bioengineering (Basel). 2023. PMID: 37106675 Free PMC article. Review.
-
Telocytes regulate macrophages in periodontal disease.Elife. 2022 Oct 4;11:e72128. doi: 10.7554/eLife.72128. Elife. 2022. PMID: 36193890 Free PMC article.
References
-
- Alessandri AL, Sousa LP, Lucas CD, Rossi AG, Pinho V, Teixeira MM. Resolution of inflammation: mechanisms and opportunity for drug development. Pharmacol Ther. 2013;139:189–212. - PubMed
-
- Slots J. Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017;75:7–23. - PubMed
-
- Frencken JE, Sharma P, Stenhouse L, Green D, Laverty D, Dietrich T. Global epidemiology of dental caries and severe periodontitis-a comprehensive review. J Clin Periodontol. 2017;44(Suppl 18):S94–S105. - PubMed
Publication types
LinkOut - more resources
Full Text Sources