Do Probiotics Improve the Health Status of Individuals with Diabetes Mellitus? A Review on Outcomes of Clinical Trials

Biomed Res Int. 2019 Dec 14;2019:1531567. doi: 10.1155/2019/1531567. eCollection 2019.


Probiotics are now considered as an adjuvant and complementary therapeutic agent for several health complications, especially for metabolic and gastrointestinal disorders because of the influential impact of probiotic consumption on gut microbiota and immunity. Diabetes mellitus (DM) is fourth, in noncommunicable disease category, leading cause of mortality, morbidity, and economic crises in the world. Though several progressions are added in the medical field in recent decades, the treatment and management of diabetic-related health issues are still challenging. The present study summarizes the effects of probiotic supplementation on the health status of diabetic patients. The relevant information was collected from Scopus, PubMed, and Google Scholar. The detailed literature survey revealed that the consumption of probiotic supplementation significantly improved the overall health condition of diabetic patients. Especially, the probiotic intervention improved the fasting blood glucose, insulin sensitivity, and systemic inflammatory and antioxidant status in type 2 diabetic (T2D) patients. Moreover, improvement of gut microbial composition and prevention of bacterial translocation has also been observed in probiotic-supplemented T2D people. Some of the studies evidenced that the supplementation of probiotics can prevent and improve the gestational DM. Nevertheless, some of the studies reported negative results and limitations in the results of clinical trials. However, further studies are mandatory to develop a concrete probiotic-based adjuvant treatment procedure to treat DM.

Publication types

  • Review

MeSH terms

  • Blood Glucose / genetics
  • Diabetes Mellitus / genetics
  • Diabetes Mellitus / microbiology
  • Diabetes Mellitus / prevention & control*
  • Diabetes Mellitus, Type 2 / microbiology
  • Diabetes Mellitus, Type 2 / prevention & control*
  • Dietary Supplements
  • Gastrointestinal Microbiome / drug effects*
  • Health Status
  • Humans
  • Insulin Resistance / genetics
  • Probiotics / therapeutic use*


  • Blood Glucose