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. 2020 Mar 16;59(12):4806-4813.
doi: 10.1002/anie.201916287. Epub 2020 Feb 4.

Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels

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Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels

Arundhati Roy et al. Angew Chem Int Ed Engl. .
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Abstract

Reported herein is a series of pore-containing polymeric nanotubes based on a hydrogen-bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 Å diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion-transport activities for iodide (EC50 =0.042 μm or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides (EC50 =0.47 μm). Notably, even in cholesterol-rich environment, iodide transport activity remains high with an EC50 of 0.37 μm. Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior-pointing methyl groups.

Keywords: hydrogen bonds; iodide; ion channels; molecular dynamics; supramolecular chemistry.

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