Anchors Away: Glia-Neuron Adhesion Regulates Myelin Targeting and Growth

Miguel A Garcia; J Bradley Zuchero

doi:10.1016/j.devcel.2019.11.018

Anchors Away: Glia-Neuron Adhesion Regulates Myelin Targeting and Growth

Dev Cell. 2019 Dec 16;51(6):659-661. doi: 10.1016/j.devcel.2019.11.018.

Authors

Miguel A Garcia¹, J Bradley Zuchero²

Affiliations

¹ Department of Neurosurgery, Stanford University, Stanford, CA, USA. Electronic address: miguelag@stanford.edu.
² Department of Neurosurgery, Stanford University, Stanford, CA, USA. Electronic address: zuchero@stanford.edu.

PMID: 31951538
DOI: 10.1016/j.devcel.2019.11.018

Abstract

Myelination in the CNS requires oligodendrocytes to first select correct axonal targets and then extend their membranes around and along these axons. In this issue of Developmental Cell, Klingseisen et al. (2019) find that the adhesion protein Neurofascin is required in oligodendrocytes for both target selection and myelin growth.

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MeSH terms

Axons
Cell Adhesion
Myelin Sheath*
Neuroglia
Oligodendroglia*