Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jan 14;52(1):4-6.
doi: 10.1016/j.immuni.2019.12.017.

(Sterol)ized Immunity: Could PI3K/AKT3 Be the Answer?

Affiliations
Comment

(Sterol)ized Immunity: Could PI3K/AKT3 Be the Answer?

Xun Chi et al. Immunity. .

Abstract

Type I interferons (IFNs) can reprogram the cholesterol biosynthetic pathway to facilitate innate immune responses. In this issue of Immunity, Xiao et al. (2020) reveal that type I IFN signaling and 7-dehydrocholesterol (7-DHC) accumulation form a positive feedback loop to amplify innate immune responses to control viral infections by activating AKT3.

Comment on

Similar articles

See all similar articles
Feedback