Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates

Cell Chem Biol. 2019 Dec 19;26(12):1631-1633. doi: 10.1016/j.chembiol.2019.12.001.

Abstract

As a key mediator of efficacy and toxicity, the linker connecting the payload in antibody drug conjugates determines cellular distribution and payload release. Sorkin et al. (2019) have created novel fluorescence-based linkers to quantify the rate of intracellular bond cleavage and track live-cell kinetics for designing more effective agents.

Publication types

  • Comment

MeSH terms

  • Cell Physiological Phenomena
  • Drug Design*
  • Immunoconjugates*
  • Kinetics

Substances

  • Immunoconjugates