An RNA Surprise in Bacterial Effector Mechanisms

Milan Gerovac; Jörg Vogel

doi:10.1016/j.chom.2019.11.005

An RNA Surprise in Bacterial Effector Mechanisms

Cell Host Microbe. 2019 Dec 11;26(6):709-711. doi: 10.1016/j.chom.2019.11.005.

Authors

Milan Gerovac¹, Jörg Vogel²

Affiliations

¹ Institute of Molecular Infection Biology (IMIB), University of Würzburg, Würzburg 97080, Germany.
² Institute of Molecular Infection Biology (IMIB), University of Würzburg, Würzburg 97080, Germany; Helmholtz Institute for RNA-based Infection Research (HIRI), Würzburg 97080, Germany. Electronic address: joerg.vogel@uni-wuerzburg.de.

PMID: 31951583
DOI: 10.1016/j.chom.2019.11.005

Abstract

Bacterial pathogens secrete effector proteins to manipulate host signaling proteins and cellular structures. In this issue of Cell Host & Microbe, Pagliuso et al. (2019) propose an effector mechanism in Listeria monocytogenes whereby an RNA-binding protein associates with bacterial RNA that stimulates RIG-I (retinoic acid inducible gene I)-based innate immunity in the host cytosol.

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MeSH terms

DEAD Box Protein 58
Immunity, Innate
Listeria monocytogenes*
RNA*
RNA-Binding Proteins
Signal Transduction

Substances

RNA-Binding Proteins
RNA
DEAD Box Protein 58