Expanding the Degradable Proteome: Designing PROTACs by the Book

Cell Chem Biol. 2020 Jan 16;27(1):14-16. doi: 10.1016/j.chembiol.2019.12.009.

Abstract

In this issue of Cell Chemical Biology, Li et al. (2020), Hsu et al. (2020), and Potjewyd et al. (2020) expand the target spectrum amenable to protein degradation by designing degraders of the cell cycle checkpoint kinase Wee1 and the polycomb repressive complex 2 (PRC2) via its regulatory EED subunit.

Publication types

  • Comment

MeSH terms

  • Books
  • Intercellular Signaling Peptides and Proteins
  • Peptides
  • Polycomb Repressive Complex 2*
  • Proteome*

Substances

  • Intercellular Signaling Peptides and Proteins
  • Peptides
  • Proteome
  • snake venom protein C activator
  • Polycomb Repressive Complex 2