Biomedical applications of laminarin

Carbohydr Polym. 2020 Mar 15:232:115774. doi: 10.1016/j.carbpol.2019.115774. Epub 2019 Dec 20.

Abstract

The ocean is par excellence a fertile territory of biodiversity on our planet. Marine-derived polysaccharides have been applied as functional materials in biomedicine due to their attractive bioactive properties, safety, high availability and low-cost production. Laminarin (or laminaran), a low molecular weight β-glucan storage polysaccharide present in brown algae, can be (bio-) chemically modified to enhance its biological activity and employed in cancer therapies, drug/gene delivery, tissue engineering, antioxidant and anti-inflammatory functions. This review provides a brief overview on laminarin characteristics, modification strategies and highlights its pivotal biomedical applications.

Keywords: Anti-tumor; Antioxidant; Beta-glucan; Laminarin; Seaweed; Tissue engineering.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Biomedical Research*
  • Cell Survival / drug effects
  • Drug Delivery Systems
  • Gene Transfer Techniques
  • Glucans / chemistry
  • Glucans / pharmacology*
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Tissue Engineering

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Glucans
  • laminaran