Characterization of chitosan-lysine surfactant bioactive coating on silicone substrate

Carbohydr Polym. 2020 Mar 15:232:115817. doi: 10.1016/j.carbpol.2019.115817. Epub 2019 Dec 31.

Abstract

Chitosan (Chi) and anionic surfactant derived from lysine (77KS) were used to prepare a novel bioactive coating and as a drug delivery system for amoxicillin (AMOX) on a model polydimethylsiloxane (PDMS) surface. The bioactive coating was formulated as polyelectrolyte-surfactant complex (PESC). Aggregation behaviour between the cationic Chi and oppositely charged 77KS in bulk was analysed using turbidity and ζ-potential measurement. Furthermore, the adsorption and stability of the formulations were evaluated using quartz crystal microbalance with dissipation (QCM-D). The effect of the ionic strength and of the ultraviolet/ozone (UVO) activation of the PDMS films on the adsorption behaviour of the PESC complex was also examined. QCM-D monitoring showed stable adsorption of bare and AMOX-loaded complex on non-activated PDMS films, while the coating on UVO-activated PDMS samples desorbed after the rinsing step. Finally, X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry confirmed successful and homogenously distributed compounds.

Keywords: Bioactive coating; Chitosan; Lysine surfactant; Polydimethylsiloxane; QCM-D; Surface analysis.

MeSH terms

  • Amoxicillin / chemistry
  • Anti-Bacterial Agents / chemistry
  • Chitosan / chemistry*
  • Coated Materials, Biocompatible / chemistry*
  • Humans
  • Lysine / chemistry*
  • Molecular Structure
  • Silicones / chemistry*
  • Surface Properties
  • Surface-Active Agents / chemistry*

Substances

  • Anti-Bacterial Agents
  • Coated Materials, Biocompatible
  • Silicones
  • Surface-Active Agents
  • Amoxicillin
  • Chitosan
  • Lysine