CRISPR gene-engineered CYBBko THP-1 cell lines highlight the crucial role of NADPH-induced reactive oxygen species for regulating inflammasome activation

J Allergy Clin Immunol. 2020 Jun;145(6):1690-1693.e5. doi: 10.1016/j.jaci.2019.12.913. Epub 2020 Jan 15.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cell Line
  • Clustered Regularly Interspaced Short Palindromic Repeats / genetics*
  • Female
  • Granulomatous Disease, Chronic / genetics
  • Granulomatous Disease, Chronic / metabolism
  • Humans
  • Inflammasomes / genetics*
  • Inflammasomes / metabolism*
  • Inflammation / genetics
  • Inflammation / metabolism
  • Macrophages / metabolism
  • Mutation / genetics
  • NADP / metabolism*
  • NADPH Oxidase 2 / genetics*
  • NADPH Oxidase 2 / metabolism*
  • NADPH Oxidases / metabolism
  • Phagocytes / metabolism
  • Reactive Oxygen Species / metabolism*
  • THP-1 Cells / metabolism*

Substances

  • Inflammasomes
  • Reactive Oxygen Species
  • NADP
  • CYBB protein, human
  • NADPH Oxidase 2
  • NADPH Oxidases