Jak Inhibition Prevents Bleomycin-Induced Fibrosis in Mice and Is Effective in Patients with Morphea

J Invest Dermatol. 2020 Jul;140(7):1446-1449.e4. doi: 10.1016/j.jid.2019.12.019. Epub 2020 Jan 16.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Animals
  • Biopsy
  • Bleomycin / adverse effects*
  • Female
  • Fibrosis / drug therapy*
  • Fibrosis / prevention & control*
  • Humans
  • Immune System
  • Janus Kinase Inhibitors / pharmacology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Middle Aged
  • Piperidines / pharmacology
  • Pyrimidines / pharmacology
  • Scleroderma, Localized / drug therapy*

Substances

  • Janus Kinase Inhibitors
  • Piperidines
  • Pyrimidines
  • Bleomycin
  • tofacitinib