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. 2020 Apr;8(4):1416-1419.e3.
doi: 10.1016/j.jaip.2019.12.041. Epub 2020 Jan 16.

Anaphylaxis to PEGylated liposomal echocardiogram contrast in a patient with IgE-mediated macrogol allergy

Matthew S Krantz  1 , Yiwei Liu  2 , Elizabeth J Phillips  3 , Cosby A Stone Jr  4
Affiliations

Anaphylaxis to PEGylated liposomal echocardiogram contrast in a patient with IgE-mediated macrogol allergy

Matthew S Krantz et al. J Allergy Clin Immunol Pract. 2020 Apr.
No abstract available

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Conflict of interest statement

Disclosures: The authors declare that they have no conflicts of interest to disclose.

Figures

Figure E1.
Figure E1.
X and Y indicate the repeating oxyethylene group. The number of repeats determines the length of the molecule’s chain, and thereby determines the molecular weight. A polyethylene glycol of molecular weight 3350 would be a mixture of molecules with enough oxyethylene repeats to have an average molecular weight of 3350 g/mol.
Figure 1.
Figure 1.
Selected skin testing images for the patient. In panel A, skin prick testing (SPT) read at 15 minutes had positive responses to polyethylene glycol (PEG) 3350 at all 3 concentrations tested. In panel B, intradermal testing (IDT) is positive for triamcinolone acetonide (contains polysorbate 80), SPT is negative for PEG 300, and IDT is negative for methylprednisolone sodium succinate, all read at 15 minutes. In panel C, SPT is positive for methylprednisolone acetate (contains PEG 3350). (Measurements are recorded in Table E1). Key: + = histamine control (0.1 mg/mL), − = saline, PEG 300 = PEG 300 full strength, MS ID = methylprednisolone sodium succinate intradermal test, TI = triamcinolone acetonide intradermal test, MA = methylprednisolone acetate
Figure 2.
Figure 2.
Cases of anaphylaxis reported to the FDA (FAERS) implicating PEGylated liposomal, human albumin, and unspecified formulations of perflutren echocardiography contrast, by year, along with annotations of key FDA boxed warning revisions. FAERS, FDA Adverse Event Reporting System; FDA, US Food and Drug Administration; PEG, polyethylene glycol.
See this image and copyright information in PMC

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References

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