Three new secoiridoid glycosides from the flower buds of Lonicera japonica

Abstract

Three new secoiridoid glycosides, named lonijapoglycol A (1), aldosecolohanin C (2) and aldosecolohanin B (3), together with three known ones (4-6), have been isolated from the flower the buds of Lonicera japonica. All the structures were identified by spectroscopic analyses. Lonijapoglycol A (1) expressed significant anti-inflammatory activity to inhibit the release of β-glu-curonidase induced by platelet-activating factor in rat polymorphonuclear leukocytes with an IC₅₀ value of 3.76 μmol·L^-1.

Keywords: Anti-inflammatory activity; Lonicera japonica; Secoiridoid glycosides; Spectroscopic analysis.