A case of combined central and peripheral demyelination in Zambia

Mult Scler Relat Disord. 2020 May:40:101943. doi: 10.1016/j.msard.2020.101943. Epub 2020 Jan 14.


Overlap syndromes, where otherwise distinct autoimmune processes of the central and peripheral nervous systems are present in the same patient, are uncommon and have not been previously reported in sub-Saharan Africa. We present a case of a 32-year-old man who was found to have both clinically isolated syndrome and chronic inflammatory demyelinating polyneuropathy, highlighting the importance of continued efforts to establish the prevalence of demyelinating disease in the region given the limited treatment options currently available for autoimmune disease.

Keywords: Autoimmune diseases; Chronic inflammatory demyelinating; Developing countries; Multiple sclerosis; Polyradiculoneuropathy; Undifferentiated connective tissue diseases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Azathioprine / administration & dosage
  • Comorbidity
  • Demyelinating Diseases / diagnosis*
  • Demyelinating Diseases / drug therapy
  • Demyelinating Diseases / epidemiology
  • Developing Countries
  • Glucocorticoids / administration & dosage
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Male
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / epidemiology
  • Prednisone / administration & dosage
  • Zambia


  • Glucocorticoids
  • Immunosuppressive Agents
  • Azathioprine
  • Prednisone