During prenatal brain development, ion channels are ubiquitous across several cell types, including progenitor cells and migrating neurons but their function has not been clear. In the past, ion channel dysfunction has been primarily studied in the context of postnatal, differentiated neurons that fire action potentials - notably ion channels mutated in the epilepsies - yet data now support a surprising role in prenatal human brain disorders as well. Modern gene discovery approaches have identified defective ion channels in individuals with cerebral cortex malformations, which reflect abnormalities in early-to-middle stages of embryonic development (prior to ubiquitous action potentials). These human genetics studies and recent in utero animal modeling work suggest that precise control of ionic flux (calcium, sodium, and potassium) contributes to in utero developmental processes such as neural proliferation, migration, and differentiation.
Keywords: bioelectricity; brain malformation; channelopathy; cortical development; encephalopathy; ion channel.
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Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex.Cereb Cortex. 2014 Apr;24(4):1017-29. doi: 10.1093/cercor/bhs387. Epub 2012 Dec 12. Cereb Cortex. 2014. PMID: 23236211
Developmental Profile of Ion Channel Specializations in the Avian Nucleus Magnocellularis.Front Cell Neurosci. 2016 Mar 30;10:80. doi: 10.3389/fncel.2016.00080. eCollection 2016. Front Cell Neurosci. 2016. PMID: 27065805 Free PMC article.
Human Cytomegalovirus IE2 Protein Disturbs Brain Development by the Dysregulation of Neural Stem Cell Maintenance and the Polarization of Migrating Neurons.J Virol. 2017 Aug 10;91(17):e00799-17. doi: 10.1128/JVI.00799-17. Print 2017 Sep 1. J Virol. 2017. PMID: 28615204 Free PMC article.
Dendritic ion channelopathy in acquired epilepsy.Epilepsia. 2012 Dec;53 Suppl 9(Suppl 9):32-40. doi: 10.1111/epi.12033. Epilepsia. 2012. PMID: 23216577 Free PMC article. Review.
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