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. 2020 Apr 1;174(4):383-385.
doi: 10.1001/jamapediatrics.2019.5513.

Rotavirus Vaccination and Type 1 Diabetes Risk Among US Children With Commercial Insurance

Rachel M Burke  1 , Jacqueline E Tate  1 , Rebecca M Dahl  2 , Sharon Saydah  3 , Giuseppina Imperatore  3 , Edward W Gregg  3 , Umesh D Parashar  1
Affiliations
Free PMC article

Rotavirus Vaccination and Type 1 Diabetes Risk Among US Children With Commercial Insurance

Rachel M Burke et al. JAMA Pediatr. .
Free PMC article

Abstract

This cohort study uses commercial insurance data to examine the association between rotavirus vaccination and type 1 diabetes incidence.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure.
Figure.. Unadjusted Type 1 Diabetes (T1D)–Free Survival Curve, by Rotavirus Vaccination Status
Type 1 diabetes–free survival curve confidence intervals overlapped among children fully vaccinated (gray) compared with children partially vaccinated (orange) or unvaccinated (blue) against rotavirus. The plot is shown beginning at age 27 weeks, by which time all children will have been eligible to be fully vaccinated against rotavirus. Children who had not yet received any doses of diphtheria-tetanus-pertussis–containing vaccines are excluded, as were those receiving a T1D diagnosis or lost to follow-up before 27 weeks. Rotavirus vaccination status is treated as time varying. Data are from the IBM MarketScan Commercial Database (formerly known as the Truven Health MarketScan Commercial Claims and Encounters database), 2006 through 2017.
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References

    1. Blomqvist M, Juhela S, Erkkila S, et al. . Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life. Clin Exp Immunol. 2002;128(3):511-515. doi:10.1046/j.1365-2249.2002.01842.x - DOI - PMC - PubMed
    1. Honeyman MC, Coulson BS, Stone NL, et al. . Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes. 2000;49(8):1319-1324. doi:10.2337/diabetes.49.8.1319 - DOI - PubMed
    1. Perrett KP, Jachno K, Nolan TM, Harrison LC. Association of rotavirus vaccination with the incidence of type 1 diabetes in children. JAMA Pediatr. 2019;173(3):280-282. doi:10.1001/jamapediatrics.2018.4578 - DOI - PMC - PubMed
    1. Vaarala O, Jokinen J, Lahdenkari M, Leino T. Rotavirus vaccination and the risk of celiac disease or type 1 diabetes in Finnish children at early life. Pediatr Infect Dis J. 2017;36(7):674-675. doi:10.1097/INF.0000000000001600 - DOI - PubMed
    1. Hemming-Harlo M, Lähdeaho ML, Mäki M, Vesikari T. Rotavirus vaccination does not increase type 1 diabetes and may decrease celiac disease in children and adolescents. Pediatr Infect Dis J. 2019;38(5):539-541. doi:10.1097/INF.0000000000002281 - DOI - PubMed

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